The game is set in a dark, gothic world filled with demons, ancient legends, and supernatural powers.

The game begins with a mysterious tower erupting from the earth in the middle of a modern city. This tower, known as the Temen-ni-gru, is the central setting of the game and holds the gateway to the demonic realm.

Dante, a young and cocky demon hunter, is unexpectedly attacked in his own shop by a demonic messenger, marking the beginning of a long night of battles. The attack was orchestrated by his twin brother Vergil, who seeks to unlock the power of their demonic heritage by accessing the underworld through the tower.

The story explores themes of family, rivalry, identity, and power. It chronicles Dante’s transformation from a reckless youth into the more mature, battle-hardened demon hunter fans know from later games. Throughout the game, Dante battles increasingly powerful demons, encounters strange allies and enemies, and gradually awakens to his full potential.